The Impact of Psychological Stress on Cancer Growth

The Impact of Psychological Stress on Cancer Growth

Detoxifying vegetables and fruits

Cancer is the leading cause of death in Canada and is responsible for 28.2% of all deaths in Canada. The statistics show that more than 2 in 5 Canadians (44% of men and 43% of women) are expected to develop cancer during their lifetime with lung, prostate, breast and colorectal cancer making up of 40% of all new cancers.

There are many contributing factors to cancer development – including genetics, environmental exposure, dietary choices, and lifestyle – but one factor that often gets overlooked is psychological stress, also known as emotional stress.

It has been well-documented that psychological stress can be a major contributing factor for many major illnesses and diseases, and unfortunately this can include the “big C” – cancer.

Stress & Cancer

When you look at the relationship between stress and cancer, the research is somewhat varied. Some experts suggest that stress can cause cancer, while others believe it may only contribute to the condition.

Stress is inevitable, and we actually need some stress in our lives. In short doses, stress can actually be healthy for us! However, research has shown that chronic, long-term stress (which in the last couple years has been something that many of us have experienced) has been found to promote and facilitate the development of cancer. This is because stress can weaken the body’s necessary functioning including immune response, and our immune system is largely responsible for keeping cancer at bay (2).

Research has also found that stress may have a greater impact on people who have already been successfully treated for cancer. In one study, researchers found that stress may reactivate dormant tumor cells, causing cancer to return in those in remission (3).

Therefore, managing stress by reducing exposure to stressors and having healthy coping mechanisms might not only help prevent cancer development but also help to reduce the risk of coming out of remission!

Coping with Stress

If you do have a lot of stress, it is important to consider one’s reaction to stress, as this may also make a difference in the susceptibility to disease. When individuals have better stress management strategies and healthy coping mechanisms in place, then their susceptibility to disease is lessened. In short, in most instances it is our reaction to a stressor that is more meaningful to our health outcomes than the details of the stressor itself.

If we find ourselves in stressful situations or environments, and feel that we have little or no control over them, this can result in feelings of hopelessness, helplessness, despair, and depression. These are the types of negative feelings can impact our bodies and predispose us to illness.

So, let’s take a deeper dive into how stress manifests into cancer…

How Stress Contributes To Cancer Growth

When we are under stress, we illicit the “fight or flight” reaction. When this occurs our limbic system (the part of our brain above our brainstem, and the area of the brain responsible for emotions) records stress, depression, and despair; and its effects on the body experienced by an individual. This leads to a response with the hypothalamus (a small region of the brain that acts as our endocrine system’s switchboard).

The messages the hypothalamus receives from the limbic system are translated to two areas of the body – the immune system and the endocrine system. The area that is most responsive to emotional stress is the immune system and regulating the pituitary gland that in turn regulates the remainder of the endocrine system (hormonal system). This is significant because an imbalance of the adrenal hormones will create a greater susceptibility to carcinogenic substances.

The result of such a hormonal imbalance can be an increased production of abnormal cells in the body and a weakened ability of the immune system to combat these cells. Our immune system is the body’s natural defense system, and it is designed to contain or destroy cancerous cells – which are normally present in the body on occasion. If the immune system is suppressed and can no longer perform the duties of containing or destroying cancer cells, it can result in the growth and proliferation of cancer cells. With this sequence of events related to stress and psychological changes, an optimal environment is now created for cancer growth.

It’s clear, emotional stress plays a huge role in suppression of the immune response, leaving the body susceptible to the development of cancer.

So, what do we do about it?

How To Better Manage Our Stress and Emotions To Help Prevent Cancer Growth

There are many strategies you can implement to support the reduction of your stress responses:

Additional Resources

Stress management and cancer prevention are topics that are relevant to nearly all of us. As a result, we’ve written many more resources to help you navigate and apply diet and lifestyle choices that support your health.

  • As identified in this article negative thought patterns and emotions impact our hormones and immune system, so developing positive mindset can be helpful. You, too, can learn how to develop some health positive mindset strategies.
  • Managing stress is key to health, so we’ve outlined some more stress management strategies.
  • Dietary changes that better manage stress hormones is also of vital importance to health. When blood sugars fluctuate too widely our bodies naturally produce the stress hormone cortisol. You can read more about the best foods to manage stress.
  • Maintaining a diet that supports blood sugar balance is another factor in preventing disease. We’ve shared the 4 easy steps to achieving a balanced diet.
  • For more on dietary strategies research shows are cancer preventative, check out 5 Nutrition Strategies for Cancer Prevention.
  • We’ve also listed our favourite foods to help prevent cancer in our article Top 6 Cancer-Preventative Foods.

We hope some of this information encourages you to do what you can to manage stress, prevent cancer, and live as many health-filled years as possible!

 

References

  1. https://www.researchgate.net/publication/354519586_Stress_and_cancer_mechanisms_significance_and_future_directions
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466429/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085740/ 

 

 

5 Nutrition Strategies for Cancer Prevention

5 Nutrition Strategies for Cancer Prevention

Ketogenic Meal

An estimated 225,800 new cases of cancer and 83,300 deaths from cancer will occur in Canada in 2020. Cancer is the leading cause of death in Canada and is responsible for 30% of all deaths.

Based on 2015 estimates nearly 1 in 2 Canadians (45% of men and 43% of women) is expected to develop cancer during their lifetime and approximately 1 out of 4 Canadians (26% of men and 23% of women) is expected to die from cancer. (Canada Cancer society)

Based on research from the New England Medical Journal of 45,000 twins it was identified that 85% of cancers are caused by environmental factors, including diet and lifestyle. Humankind has invented 10 million new chemicals and unwittingly released thousands of these into our environment, many of which are known as carcinogens. In fact, the growth in the incidence of cancer parallels the industrialization and chemicalization of our world, which is why we are likely seeing the ongoing rise of cancer rates over the last century(1) .

Specific to the impact of nutrition, the World Cancer Research fund indicated that eating the right diet may cut your risk of cancer by up to 40%. The key organs that help to fight off cancer are your liver and your immune system, so nutrition support to help these organs function at their best is important. We also want to help create a terrain within our bodies that is not conducive to cancer growth, which includes having a more alkaline state.

So, let’s have a look at what dietary changes you can make to help reduce your risk of getting cancer:

1. Consume at least 7 servings of fruits and vegetables a day

(ideally organic to reduce chemical exposure).
You should also include a rainbow of colours to ensure you are consuming a wide-range of cruciferous vegetables daily, such as broccoli, Brussel sprouts, cabbage, cauliflower and kale helps support the liver the key organ in helping to combat cancer.Fruits and vegetables contain antioxidants which extensive research is showing can help treat and prevent cancer. In a scientific review of 206 human and 22 animal studies it was shown that greater fruit and vegetable intake has a protective effect with cancers of the stomach, esophagus, lung, oral cavity, pharaynx, endomedtrium, pancreas and colon (2). We must also consider that cancer thrives in a low-oxygen, acidic environment (Cancer Research Journal 2006) and eating fresh fruits and vegetables, especially dark leafy greens, is great way to help increase the pH levels in the blood which puts the body in a more alkalinize state making it a more difficult environment for cancer cells to grow. Where as grains, coffee and sugars lower pH levels making the body more acidic so these foods should be avoided.

2. Reduce red meat intake

This includes beef, pork, lamb and goat and processed meats such as hot dogs, sausages, deli meats. Red meat is acidic to the body which creates an environment conducive to cancer growth. The World Cancer Research Fund recommended if you do eat red meat this should be limited to at most 500 grams a week). One study found that women who ate red meat every day had a 56% increase risk of breast cancer (4). Plus, research shows that people that consume higher amounts of red meat are at greater risk of stomach, pancreatic and breast cancer(3). Red meat consumption in countries that inject growth hormones and other hormones to increase milk supply can increase the risk of hormone-based cancers such as breast and prostate.

If you are consuming red meat opt for organic, grass-fed beef, lamb or game, as these meats are less inflammatory than their factory-farmed counterparts. Maintaining a focus on lean organic, free-range eggs, poultry and game, wild-caught fish, and vegetable-based proteins is important.

Processed meats contain N-nitroso compounds (NOCs), which can damage DNA and contribute to cancer development. High cooking temperatures may produce additional carcinogens in meats. You should especially avoid chargrilled meat on the BBQ and frying as this is creates well-known carcinogens and increases the risk of stomach and colorectal cancer. A healthier cooking option is frying foods in a little water as opposed to oils, which often become rancid at high heats.

3. Avoid sugar.

Cancer cells usually grow quickly, and multiply at fast rates, which takes a lot of energy – this means they need lots of glucose. Cancer cells thrive on sugar. In fact, individuals with type 2 diabetes have three times the risk of developing cancer. A diet rich in sugary foods and beverages can lead to obesity, which significantly raises your risk of cancer (5). Cancer Research UK reports eating high amounts of sugar over time can cause you to gain weight, and robust scientific evidence shows that being overweight or obese increases the risk of 13 different types of cancer. Obesity is the single biggest preventable cause of cancer after smoking.

Additionally, sugar is acidic to the body and cancer tends to thrive in acidic environments. Diets high in sugar increase inflammation in your body and may lead to insulin resistance, both of which increase cancer risk (6). A study in over 430,000 people found that added sugar consumption was positively associated with an increased risk of esophageal cancer, pleural cancer and cancer of the small intestine (7).

4. Limit Alcohol

Alcohol is one of the top three causes of cancer deaths worldwide. Last year, it is estimated that as many as 10,700 Canadians were diagnosed with cancer linked to their alcohol consumption (Canadian Cancer Society). A survey showed that 60% of Ontario women and 41% of Ontario men exceed the alcohol consumption guidelines recommended by the Canadian Cancer Society.  

The National Toxicology Program of the US Department of Health and Human Services lists consumption of alcoholic beverages as a known human carcinogen. The evidence indicates that the more alcohol a person drinks—particularly the more alcohol a person drinks regularly over time—the higher his or her risk of developing an alcohol-associated cancer. Both light drinkers (those who have no more than one drink per day) and binge drinkers have an increased risk of some cancers (8-12). 

Alcohol consumption can increase the risk of mouth and throat, larynx, oesophagus, breast, liver and bowel cancer. The Canadian Cancer Society recommends that women have less than one standard drink per day and men have less than two standard drinks per day.

 

While there’s no one thing any of us can do (or not do) to ensure with certainty that we don’t develop cancer, there are many diet and lifestyle changes that we can make as individuals in order to give ourselves the best chance possible of a long and healthy life!

Download our free 1-day cancer preventative meal plan as a kick-start to altering your diet in a way that will help prevent the development of cancer.

If you want to take things a step further, we would love to meet with you one-on-one to complete a thorough assessment to help determine your risk of developing cancer and help educate you about diet and lifestyle changes you can make to reduce your risk.

 

References

  1. Waller “the disease of civilization” Ecologist, 1970:1(2)
  2. https://www.ncbi.nlm.nih.gov/pubmed/8841165
  3. Nothlings and L.N Kolonel “Risk factors for Pancreatic cancer in the Hawaii-Los Angeles Multiethnic cohort study Hawaii Medical Journal, 2006 Jan,:65 (1):26-8
  4. F Taylor , et al “meat conusmtoion and risk of breast cancer in the UK Womens Cohort Dtudy” British Jounral of Cancer, 2007, April 10;96 (7): 1139-46
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773450/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595327/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494407/
  8. Bagnardi V, Rota M, Botteri E, et al. Light alcohol drinking and cancer: a meta-analysis. Annals of Oncology 2013; 24(2):301-308. [PubMed Abstract]
  9. Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. British Journal of Cancer 2015; 112(3):580-593. [PubMed Abstract]
  10. Cao Y, Willett WC, Rimm EB, Stampfer MJ, Giovannucci EL. Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies. BMJ 2015; 351:h4238. [PubMed Abstract]
  11. Chen WY, Rosner B, Hankinson SE, Colditz GA, Willett WC. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 2011; 306(17):1884-1890. [PubMed Abstract]
  12. White AJ, DeRoo LA, Weinberg CR, Sandler DP. Lifetime alcohol intake, binge drinking behaviors, and breast cancer risk. American Journal of Epidemiology 2017; 186(5):541-549. [PubMed Abstract]

 

Top 6 Cancer-Preventative Foods

Top 6 Cancer-Preventative Foods

Ketogenic Meal

There is growing research on the power of foods and the impact on preventing, or even addressing, cancer. This is empowering for people who are at risk or who have cancer!

All of us have “cancerous” cells in our bodies at all times – this is normal. Our bodies are constantly making new cells, and sometimes things go wrong. However, in a healthy body, the number of these cells is small enough that our immune system is able to detect the cancerous cells and destroy them before they have the chance to get out of control. Many of the foods below help to prevent cancer development because they either support the healthy division of new cells (meaning the body makes fewer mistakes), or because they support the immune system in targeting cancer cells, or both!

Let’s explore our top 6 foods that can help us fight cancer.

1. Turmeric

The Indian spice, turmeric, is anti-inflammatory, anti-viral, anti-bacterial, anti-fungal, and can be extremely helpful when it comes to fighting cancer. Studies show that the active compound curcumin, found in turmeric, may help to kill cancer cells and slow tumor growth (1).

The research on the benefits of curcumin with cancer show that it can help protect against every stage of cancer development including initiation, promotion and progression. Curcumin has been shown to block cancer cells from multiplying, and in killing colon, breast, prostate, and melanoma cancer cells as well as slowing or inhibiting tumor growth (2).

2009 study found that curcumin can kill many types of cancer cells in multiple ways. Because more than one method is possible, cancer cells are less likely to become curcumin-resistant. Curcumin targets only cancer cells, leaving healthy cells unaffected. This is an important step in potential treatment because chemotherapy drugs kill both healthy cells and cancer cells (3).

Add some turmeric to your next dinner, take a supplement containing curcumin to experience the benefits of this powerful substance, or make a Golden Milkshake.  Link to recipe

  1. https://academic.oup.com/jnci/article/100/9/616/917868
  2. Krishnaswamy, et al Retardation of experimental tumorgenisis and reduction in DNA adducts by tummeric and curcumin, Nutrition and cancer  1998; 30 (2): 163-6
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758121/

2. Garlic

The American Institute of Cancer indicates that there are many ways in which garlic and its compounds may help prevent cancer. Lab studies show that garlic compounds help with DNA repair, slow the growth of cancer cells, decrease inflammation and prevent the formation of carcinogenic substances in the body. A 2019 study further supported the role of garlic in DNA repair in that (at least in the lab) garlic appeared to enhance the expression of tumor suppressor genes.

Garlic has natural antioxidants and is anti-inflammatory, antibacterial, and antiviral. It contains high levels of sulfur, flavonoids, and selenium all of which are nutrients that support our liver and immune system. Plus, when it is crushed, chopped, or bruised, garlic produces the compound allicin which can help inhibit tumor growth (7).

Garlic contains allyl sulfur and other compounds that slow or prevent the growth of tumor cells. Allyl sulfur compounds, which occur naturally in garlic and onions, make cells vulnerable to the stress created by products of cell division. Because cancer cells divide very quickly, they generate more stressors than most normal cells. Thus, cancer cells are damaged by the presence of allyl sufur compounds to a much greater extent than normal cells (1).

After a review of the global research, AICR’s reports found that eating garlic frequently lowers the risk of colorectal cancers and breast cancer, stomach, colon, lung and prostate (2,3,4,5,6).

Based on the research, eating 2–5 grams (approximately one clove) of fresh garlic per day, or 300 to 1,000 milligrams of garlic extract, reaps benefits.

  1. https://www.medicinenet.com/script/main/art.asp?articlekey=23591
  2. https://www.tandfonline.com/doi/full/10.1080/01635581.2019.1651349
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366009/
  4. https://cancerpreventionresearch.aacrjournals.org/content/6/7/711?sid=179e57a9-3770-409d-84bc-cd83ef816963
  5. https://www.ncbi.nlm.nih.gov/pubmed/12419792/
  6. https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/garlic-fact-sheet
  7. https://cancerres.aacrjournals.org/content/20/4/431

 3. Green tea

Green tea is an excellent antioxidant, and studies show the properties of green tea help protect against metastasis of certain kinds of cancer (1). Green tea also contains chemicals called polyphenols that have antioxidant and anti-inflammatory properties. The nutrient EGCG in green tea can help induce cell death in human cancer cells.

A comprehensive review of observational studies found that women who drank had an approximately 20–30% lower risk of developing breast cancer, one of the most common cancers in women (2). Another study observed that men drinking green tea had a lower risk of advanced prostate cancer (3) and an analysis of 29 studies showed that those drinking green tea were around 42% less likely to develop colorectal cancer (4).

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142888/
  2. https://www.ncbi.nlm.nih.gov/pubmed/19437116
  3. https://academic.oup.com/aje/article/167/1/71/185454
  4. https://www.ncbi.nlm.nih.gov/pubmed/28454102 

 4. Cruciferous Vegetables

Cruciferous vegetables include arugula, bok choy, broccoli, Brussels sprouts, cabbage, cauliflower, kale, radish, and turnips.

All cruciferous vegetables contain glucosinolates, natural substances that break down during chopping, cooking, chewing and digestion into biologically active compounds called isothiocyanates and indoles. In laboratory experiments in rats and mice, these compounds have been found to inhibit cancers of the bladder, breast, colon, liver, lung and stomach. They protect cells from DNA damage by inactivating carcinogens and decreasing inflammation. Plus, they can help inhibit the formation of blood vessels and the migration of tumor cells, two processes that help spread cancer.

Cruciferous vegetables also contain other protective compounds, including carotenoids, plant pigments that may control abnormal cell growth; vitamin C, which acts as an antioxidant, protecting cells and supporting the immune system; and folate, which may also help to maintain healthy DNA and keep cancer-promoting genes turned off (1).

One analysis of 35 studies showed that eating more cruciferous vegetables was associated with a lower risk of colorectal and colon cancer (2).

  1. https://www.nytimes.com/2018/12/07/well/eat/do-cruciferous-vegetables-really-fight-cancer.html
  2. https://www.ncbi.nlm.nih.gov/pubmed/23211939

 5. Flax seed

Lignans are plant compounds that have antioxidant and estrogen properties, both of which can help lower the risk of cancer and improve health (1).

Some studies have shown that consuming 25 grams of flaxseed a day may reduce tumor growth in breast and prostate cancer. It can also reduce the body’s production of estrogen, so its benefits have been linked to breast cancer prevention. In fact, consuming flaxseed can enhance the effectiveness of tamoxifen, a drug commonly used to prevent breast cancer recurrence (2). 

The American Institute of Cancer Research reported that in a one month-long trial of about 30 post-menopausal women with newly diagnosed breast cancer, daily flaxseed consumption decreased signs of cancer cell growth. In several studies of healthy women consuming flaxseed daily, estrogen levels decreased or shifted to more of a relatively inactive form, resulting in less estrogen in the form believed to promote breast cancer growth.

Additionally, according to a Canadian study involving more than 6,000 women, those who eat flax seeds are 18% less likely to develop breast cancer (3). Further studies show benefits with colon, prostate and lung cancer (4,5)

  1. https://www.ncbi.nlm.nih.gov/pubmed/17301257
  2. https://www.mdanderson.org/publications/cancerwise/3-nutrients-cancer-survivors-should-know-flaxseed-omega-3s-iron.h00-159305412.html
  3. https://www.ncbi.nlm.nih.gov/pubmed/23354422
  4. https://www.ncbi.nlm.nih.gov/pubmed/15134976
  5. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1541-4337.2009.00105.x

 6. Berries

The researchers, led by Dr. Minna Rahnasto-Rilla, found that one type of anthocyanin, known as cyanidin, found in wild bilberry, raspberry, and cranberry, appeared to reduce the activity of cancer-causing genes and boost the activity of cancer-stopping genes (1).

Studies show that several antioxidants in berries, including anthocyanins, ellagic acid, and resveratrol, may reduce cancer risk (2,3,4). Specifically, animal and human studies suggest that berries may protect against cancer of the esophagus, skin, lung, mouth, breast, and colon (5, 6,7,8,9).

Most berries also contain antioxidants, fiber, and vitamin C which can all support a healthy immune system and liver function which is important to creating a terrain within the body that is not favourable to cancer growth. 

It’s ideal to consume berries daily, with attention to consuming a variety of different berries. Berries can be put in smoothies, on salads, with plain Greek yoghurt, on oatmeal, or just eaten on their own. Be sure to choose organic to avoid unnecessary exposure to pesticides and other chemicals, which are known carcinogens. 

  1. https://www.medicalnewstoday.com/articles/321410#Berries,-cancer-genes,-and-the-future
  2. https://www.ncbi.nlm.nih.gov/pubmed/25788047
  3. https://www.sciencedirect.com/science/article/abs/pii/S0963996911002572
  4. https://www.ncbi.nlm.nih.gov/pubmed/16084717
  5. https://www.ncbi.nlm.nih.gov/pubmed/19139022
  6. https://www.ncbi.nlm.nih.gov/pubmed/24222110
  7. https://www.ncbi.nlm.nih.gov/pubmed/22571764
  8. https://www.ncbi.nlm.nih.gov/pubmed/22823889
  9. https://www.ncbi.nlm.nih.gov/pubmed/21123457

Those are our top 6 cancer-preventative foods – turmeric, garlic, green tea, flaxseed, cruciferous vegetables and berries!

We’ve done some of the legwork for you do pack more of these protective foods into your diet and are offering our free 1-day cancer preventative meal plan for download.

If you want to take things a step further, we would love to meet with you one-on-one to complete a thorough assessment to help determine your risk of developing cancer and help educate you about diet and lifestyle changes you can make to reduce your risk.